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Skibidi vibes in the lab as fermentation unleashes penicillin magic from Penicillium spp., goon energy all around. The thiozolidine and B-lactam rings are the dank duo that take down Gram-positive bacteria, lowkey causing cell death. But watch out for the Beta-lactamase goons, like Staph aureus, who hydrolyze this sigma superstar. With semi-synthetic warriors like cloxacillin and ampicillin, the ship sails against the tide of resistant bugs. Feedback loops are the edge of this biosynthetic game, as lysine levels keep α-AAA in check, ensuring penicillin production flows. It is a biochemical battle royale.