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Histology explores the body's tissues and their arrangement in functional organs. It encompasses tissue biology, from cellular biology to microscopic anatomy, emphasizing how cell activities, shapes, and groupings optimize organ functions. Tissues consist of cells and extracellular matrix (ECM), which includes various macromolecules like collagen fibrils. The ECM supports cells, transports nutrients, and removes waste. Cells produce the ECM and are influenced by its components. During embryonic development, cells and their matrices specialize, forming fundamental tissue types. Organs arise from these tissues, allowing coordinated function within the organism.